An old Sioux shaman asks Jack Slade to come to the Twin Peaks Sioux Reservation to look into a series of killings that have apparently been perpetrated by a rogue wolf. When he arrives at the reservation, Slade discovers that the killings are being done by a Sioux who shape shifts into the form of a wolf. Slade's discovery that similar killings happening in a nearby town are being done by a second shape shifter leads him to the additional discovery...