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Paperback The Regulation of Expression of Terminal Deoxynucleotidyl Transferase in an Inducible Murine Pre-B Cell Line Book

ISBN: 0530018586

ISBN13: 9780530018584

The Regulation of Expression of Terminal Deoxynucleotidyl Transferase in an Inducible Murine Pre-B Cell Line

Abstract:

The purpose of this study was to understand the control of synthesis of Tdt at a molecular level, using a murine pre B-cell line inducible for the enzyme. FLEl-4, an Abelson virus transformed fetal liver cell line, when treated with dibutyryl cAMP and caffeine (or other phosphodiesterase inhibitors), shows a three- to tenfold induction of Tdt, as measured by immunoprecipitation of pulse labelled enzyme, activity assays, and steady-state...

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