In the 1850s, the world's foremost scientists, capitalists, and statesmen saw the Darien wilderness in eastern Panama as the perfect spot to build a great canal linking the Atlantic and Pacific Oceans. Ships from three continents raced to this largely unexplored region, but the twenty-seven-man U.S. Darien Exploring Expedition, led by an ambitious, adventure-driven navy lieutenant named Isaac G. Strain, made sure it got there first. Misled by fraudulent...