The Biochemical Basis of Neuropharmacology

This classic text has been replaced by 'Intro to Neuropsychopharmacology', by 2 of the same authors, also published by Oxford University Press (Iverson, Iverson, Cooper, Bloom; Nov. 2008).

Although a bit dry in parts, it gives a good picture overall of how neurotransmitters and brain receptors work. A comprehensive book about the fields of neurochemistry and neuropharmacology.

This reference is easy to read. As well, unlike most pharmacology texts, this one does not concentrate on drugs, but rather on the underlying physiology. There is an introduction to neurons, synapses and action potentials. There is an introduction to modern molecular methods. It is interesting to note that in describing molecular cloning methods, the work of J. G. Sutcliffe, R.J. Milner, and F.E. Bloom is reported whereby a cDNA library was prepared from mRNAs from whole rat brain, then it was seen what individual cDNAs hybridized with the mRNAs from rat liver and kidney. Approximately 30,000 of the brain's 50,000 mRNAs were not detected in the liver or kidney, showing that much of the rat's DNA is for neuronal purposes. In the introduction to receptors, it is noted that there about a thousand known receptors to neurotransmitters, hormones and odorants. The introduction to neuromodulators includes the neuronal effects of nitric oxide (thought to be involved in both long-term potentiation LTP and long-term depression LTD; nitric oxide synthase inhibitors will block NMDA receptor activation). The chapter on amino acid neurotransmitters includes excitatory glutamate and aspartate, and inhibitory GABA, glycine, alanine, cystathionine and serine. There are chapters on cholinergic (acetylcholine) and catecholaminergic (norepinephrine, epinephrine and dopamine) neurotransmitters. Serotonin and histamine neurotransmitters are considered in detail in the next chapter. There is an introduction to neuroactive peptides, noting that they must be synthesized on ribosomes, then at the smooth endoplasmic reticulum they are put into vesicles in a prohormonal form, and only then transported to the nerve terminals. The book concludes with introductions to the cellular mechanisms involved in learning, and the involvement of neurotransmitters in neurological and psychiatric illnesses.

This book is an excellent introductory text, suitable for undergraduates or "outsiders", outlining the basic principles of neuropharmacology. Reviews of the major concepts involved in neurotransmission are included in the first half of the book, such as cellular and molecular (read DNA) biological basics as well as descriptions of amino acid based neurotransmission. The second half of the book is organized with each chapter devoted to a single molecule. My major criticism is that although the title is "The BIOCHEMICAL Basis of Neuropharmacology", the chemistry in the text is rather simple and incomplete, and the lack of quantitative discussion of pharmacokinetics is a major disappointment. All beginning students of neuropharmacology should purchase this book - in paperback it is truly a bargain. END