Side Effects: A Prosecutor, a Whistleblower, and a Bestselling Antidepressant on Trial

In this gripping expose, Alison Bass manages to turn the inner workings of medical research, clinical trials and the legal system into a literary page-turner. Through tireless reporting, she brings to life several characters who made a huge impact in one small corner of the pharmaceutical industry, while also laying bare a medical system that continues to put Americans at risk. This is an important book that deserves much attention.

It's horrifying to read about our dependence on drugs. I was shocked with the first story: A teenager feels uncomfortable in social situations. She sees an ad on television promising a drug to turn teens from wallflowers to social butterflies. She asks her doctor for the drug. No problem, he says. He's not a psychiatrist, but he is an MD. Aside from concerns about effects of these drugs on children and young people, why doesn't someone ask why doctors encourage patients to seek solutions in a bottle? How is depression diagnosed (or over-diagnosed)? Then we have a story of a psychiatrist at Brown University who appears to be billing the government for research he's not conducting. He's also adjusting research reports to discount side effects. He's still around, still holding a prestigious position at Brown University, still receiving research grants. Author Bass also quotes a disturbing statistic: doctors who accept money from pharmaceutical companies (for research, consulting or testifying) tend to prescribe a lot more medication than those who don't. The fiery, likeable prosecutor battles her own vision problems as well as the pharmaceutical industry. It's frustrating to read about the legal minutiae she has to address while people are dying from these drugs. The judge's name sounds familiar: I believe she was also the judge in the Martha Stewart case. At the end of the book, we learn that the troubled teen lost her pill-induced "suicidal ideation" after discontinuing Ambien and Paxil. She has learned to accept her personality and she's found the perfect job as a veterinary technician. That's the good news. But as Bass reports, FDA reports still depend on doctors who accept money from drug companies, but claim they remain unbiased. Maybe they could work on a drug to cure their deep denial.

This account of shady goings on in the U.S. drug-industrial complex is an eye-opener. Even though the subject matter might seem a bit sterile -- clinical trials, the FDA, the pharmaceutical industry, and university researchers -- Side Effects is a delightful page-turner. The reader is drawn into the lives of the characters and the details of their compelling stories as if one were reading a novel or detective story. Side Effects is a must read in our pill-popping culture.

Alison Bass brings all the players to life, both the good and the bad, in this well documented story behind the NY Attorney General's legal action against GSK. This book is in the tradition of Erin Brokavich or A Civil Action; it reads like a novel, like a thriller in fact, only it's true. No one could make this stuff up. I could not put it down. Bass deserves a lot of credit for her courage in writing this. Not only does she expose the underbelly of academic research at prestigious Ivy League schools, but also uncovers the sordid manipulation of patient advocacy groups like NAMI by pharmaceutical interests. Nothing is sacred. She goes after it all and it's a story that needs to be told in full just as it is here. I hope it will be widely read. It is a useful and exciting addition to the many books coming out about the corruption in the pharmaceutical industry, academic research, and the regulatory authorities, bringing it down to a very human level.

Side Effects reads like a novel, even though it is a factual, non-fiction book. It is a well-written, outstanding story that depicts how several pharmaceutical firms along with the FDA intentionally did not disclose the negative, suicidal side affects of anti-depressant drugs such as Paxil, Prozac and Zoloft. Alison Bass weaves this story through a few victims and researchers who were trying to get out the truth and stand up against some very powerful, manipulative and well-financed pharmaceutical companies who make billions of dollars from these drugs. A must read!