Thoroughly revised, the third edition of this highly successful introduction to the pathophysiology of the kidney includes new material on such topics as acid excretion, dietary protein and renal function, the role of the mesangium, the biochemical nature of fixed glomerular anionic sites,osmolality of cells, chloride transport in renal tubules, ion pumps, intracellular calcium levels and their regulation, and magnesium depletion and excess.