Refractory Depression Current Strategies and Future Directions Edited by Willem A. Nolen Psychiatric Centre Bloemendaal, The Hague, The Netherlands Joseph Zohar The Chaim Sheba Medical Center, Israel Steven P. Roose New York State Psychiatric Institute, New York, USA Jay D. Amsterdam Department of Psychiatry, University of Pennsylvania, USA As many as 30% of depressed patients fail to respond to conventional antidepressant therapy, and 15% may develop...