Trisomy 21 is the most common genetic disorder in humans. The present volume reviews the results of molecular and cytogenetic techniques performed on four organisms--humans, mice, "Drosophila," and yeast. Examined are the association between meiotic recombination and chromosome disjunction, increasing maternal age and non-disjunction in humans, and genetic factors that may contribute to a predisposition to non-disjunction. Molecular analyses involving...
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