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Hardcover Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation Book
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ISBN: 3642246311

ISBN13: 9783642246319

Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation

(Part of the Springer Theses Series)

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Format: Hardcover

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Book Overview

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related...

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