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Paperback Differential Wnt/Wingless Dysregulation in Intestinal cancers Book
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ISBN: 363966759X

ISBN13: 9783639667592

Differential Wnt/Wingless Dysregulation in Intestinal cancers

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Wnt/Wingless pathway dysregulation leading to -catenin stabilization, a central downstream component is widely associated with Intestinal carcinogenesis. Majority of tumors arise as a result of mutational inactivation of tumor suppressor gene Adenomatous Polyposis Coli (APC). This study identifies alternative mechanism of -catenin stabilization in tumors that lack APC mutations. Tumor known to lack APC mutations, small bowel cancers and early age...

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