The therapeutic end point of destabilization of abnormal methylation enzymes is terminally differentiated cells. This end point is compatible with the end point on the therapy of hematological cancers. It can fit in on the therapy of hematological cancers, but it will not be easy for the acceptance on the therapy of solid cancers. In combination with surgery, or cytotoxic chemotherapy to pursue the end point of tumor disappearance is perhaps an easy...