It begins when mountain matriarch Granny Mustard decides she wants to live forever, but then is killed. Her slow-witted but equally hardheaded granddaughter Jenkie decides to pick up the ball and run with it, taking Granny's unperfected immortality moonshine recipe, a socially-inept friend named Bink, and dreams of fame and fortune to an abandoned trailer up in Desper Hollow. But slow-witted can't stand against the terrible power Granny initiated...