Biostatistics: A Methodology for the Health Sciences

This text is a great reference for everything from basic analysis to more advanced topics like longitudinal and time-to-event data. The book is well-written with relevant, current examples. If I had to choose one reference book, this would be it because of its depth and breadth of content (at the intermediate level).

The authors write well and cover most of the important topics very thoroughly. They motivate the subject very well with a number of important and "real world" examples in the first chapter.A unique feature is its detailed coverage of sample size determination in a number of contexts.The book was published in 1993 which is not recent enough to cover advances in meta analysis, resampling, Bayesian Hierarchical Models (with Markov Chain Monte Carlo Methods) and frailty models. At least bootstrap methods and meta analyses are mentioned in the book.Noteworthy are the full chapters on multiple comparison problems and discriminant analysis. This is an excellent reference book for biostatisticians.