Big Shot: Passion, Politics, and the Struggle for an AIDS Vaccine

Patricia Thomas writes a phenomenal book of science, of politics, of a deadly disease, intertwined with business and the age-old struggle of societal good vs. personal/business gain. I was at first daunted by the size of the book alone, but the writing is so clear, so concise, so reader-friendly that it is an easy read. This is a must read for everyone interested in finding solutions to science-society issues such as AIDS. It is a must read for every health care professional and medical researcher, as well. As a science/health writer myself, I also highly recommend it as a teaching tool for how to write science for the lay person.

I think "Big Shot" is the first important nonfiction work of the 21st century. With a clarity and an exuberance not often found in books about hard science, Patricia Thomas explains how politics, human frailty and corporate greed have prevented us from finding a vaccine for AIDS. Comparisons with previous books about AIDS and public policy don't exactly do justice to "Big Shot." If books must be categorized, Thomas' scrupulous research sometimes places this book with top ranking medical journals; but the wonderful writing -- you can almost dance to Thomas' prose -- places it among the better mysteries. In the hands of a lesser writer, the workings of DNA, retroviruses, surface antigens and hard-working proteins would cause one's eyes to glaze over. Instead, I found myself turning pages with Evelynwoodesque speed to get to the next development and the next, wondering which young researcher would win the race to the vaccine goal. Thomas has raised the bar for future books about medical research.

Sept. 11 has had a galvanizing effect in reminding Americans that planet earth is really a small place where whatever affects one person ultimately affects us all. The emergence of AIDS in the early 1980s might also have united Americans to fight a common enemy. Might have. But the truth, so compellingly told by Ms. Thomas, is that personalities and politics (both personal and national), prejudice and posturing got in the way of mounting a cohesive campaign. As a result, we are still far from stopping AIDS. Sure, treatments are better, but most of the world cannot afford treatment.What makes "Big Shot" especially timely is that, as America prepares to fight the "new war," more military personnel will likely be exposed to the AIDS virus. When the GIs line up for vaccinations and grimace comically for the camera, as our fathers and grandfathers did for previous wars, protection against the AIDS virus won't be part of the cocktail. Because there is no vaccine against AIDS.It's a pretty depressing scenario, but Ms. Thomas retains a wonderfully upbeat message with the subtext "that was then, this is now, so let's move forward."Besides, she tells a helluva entertaining story.

It's been said that politics, like sausage, is best not seen in the making. But those who wonder why we don't yet have a vaccine or a cure for AIDS need to know why. Pat Thomas takes us behind the scenes and lives of the cast of characters deeply involved in the science, politics and business of one of the most hotly sought-after pharmaceutical products of all time."Big Shot" gives us reason to despair that science can ever succeed, given the private and public agendas of so many involved in the AIDS epidemic.But it also gives us hope, as we see the many dedicated to finding a way to stop the spread of an epidemic that has already claimed 22 million lives. This is a masterful job by one of the best science writers working today -- wonderfully written and compelling.