At War Within: The Double-Edged Sword of Immunity

This was one of those books I purchased quite a while ago when I was in an HIV lab and I put it aside, and never quite got around to reading it. In the midst of a summer heatwave where I didn't want to go out to the library, and was browsing for something I hadn't read, I got back to this book. And...what a book it is!!! Immunology can be one of the most mind-boggling difficult things to understand, yet Clark, who is obviously at the forefront of this area of medicine, really knows how to make this information accessible to even the least scientifically-minded laymen. I actually pick up the book and was looking at something specific in the middle of the book. I couldn't put it down again til I read the rest of the book and then went back and read the first part of the book. It still made sense, and that's not easy to do coming into a science like this. This book should be required reading for all those in immunology or any of the side fields that end up using antibodies in their work, like we did to determine what type of growth factors were being churned out by the introduction of HIV to nerve and astrocytes. It makes the work much more understandable and interesting to those doing the technical work. It would be great if they could get Clark to update the book if he is around, with what new information has been discovered over the last few years in this field. This is also a must-read for anyone interested for self or family members undergoing autoimmune problems, as it explains why the body would turn around and attack itself. Since so many diseases are being determined to have an autoimmune part (as well as a trigger from a virus or bacteria) this becomes essential reading. Earl Dennis' review of this book is also a must-read, as I agree with everything he says and he says it so humorously! Karen SAdler

Clark's description of the war being waged within all of us demarcates the front lines: where our immune system (however functional or dysfunctional it may be) must constantly react to foreign microorganisms and our own cells. Not only does Clark discuss congenital immune diseases that leave some of us in various states of vulnerability, he also goes into detail about allergies, asthma, TB, viral hepatitis B, and other diseases in which the immune system wreaks havoc in the body, causing more damage than the intruding antigens. Prior to his description of the war within, he provides a brief history of vaccination and an overview of the immune system's anatomy. The second half of the book contains chapters on the devastation of AIDS, the ethical dilemmas surrounding immunosuppresants and organ transplantation, and an insightful description of the electrochemical dialogue between the brain and immune system. The final chapter of the book explains how immunological thought developed during the 20th century, culminating in Burnet's clonal selection theory - which explains how we can protect ourselves (usually) against a seemingly infinite universe of pathogens without destroying our own bodies (usually). Great read, great book!

Most neurosurgeons and astrophysicists are busy constructing the future. Some of these overacheivers suffer from a mild mental disorder called hypergraphia and compulsively write stuff down. Fortunately Dr. William Clark suffers from hypergraphia and we benefit hugely because we can look into his mind by reading his books, and what a view it is. This book is essentially about mammalian immunology. Immunology is an odd subject to get because its quite dynamic, meaning its operation is determined by a wide array of parts. Clark's book is short, sweet and to the point. He covers the basics and proceeds with case studies that bring the lay reader close to his profession without having to spend years in postdoc research doing so. His opening account of the rancerous competition between France's Louis Pasteur and Germany's Robert Koch is fantastic reading for the bonified dork. Most interestingly, Clark primes us with some genetic engineering technique in his marvelous description of SCID, severe combined immune deficiency, and its concomitant 'magic bullet' cure based on the gene therapy associated with a monogenetic disorder; interesting stuff here. His coverage of autoimmune disorders alone makes this brief, action packed essay worth the price. Clark makes the mind numbing world of immunology a little bit friendlier here.

This is a fantastic book if you want to begin to know how your body and immune system work. From colds to cancer, It simplified and helped me to know how to begin the course of a natural cure. It put years of study about disease in real focus.