Fourteen-year-olds Ana and Mario can't stand each other yet find themselves on the same school field trip to Rome. As they visit the Sistine Chapel and observe the famed frescoes on its ceiling, Ana hears a cry for help from the Cumaean Sibyl, an ancient and mysterious prophetess cursed to live for a thousand years. Later that night, Ana sneaks out of her hotel room and onto the streets of the Italian capital, determined to undertake her rescue mission...